Magnesium for T cells: strong to the finish!

Vardhana S, Dustin ML.

Trends Immunol. 2022 Apr;43(4):277-279.


Popeye, the Sailor’ cartoons taught children that eating spinach boosts strength and helps defend against bullies. Lötscher and colleagues report that dietary deficiency of magnesium ions (Mg2+), against which eating spinach is an excellent antidote, impairs the activity of a key adhesion molecule, LFA-1, and hinders the ability of CD8+ T cells to grapple with assorted bullies, such as tumors and bacteria.