Understanding T-cell responses to COVID-19 is essential for informing public health strategies

Vardhana S, Baldo L, Morice WG 2nd, Wherry EJ.

Sci Immunol. 2022 Mar 24:eabo1303.


Durable T-cell responses to SARS-CoV-2 antigens after infection or vaccination improve immune-mediated viral clearance. To date, population-based surveys of COVID-19 adaptive immunity have focused on testing for IgG antibodies that bind spike protein and/or neutralize the virus. Deployment of existing methods for measuring T-cell immunity could provide a more complete profile of immune status, informing public health policies and interventions.